Effects of Mongersen (GED-0301) on Endoscopic and Clinical Outcomes in Patients With Active Crohn’s Disease
نویسندگان
چکیده
منابع مشابه
Impact of patient characteristics on the clinical efficacy of mongersen (GED-0301), an oral Smad7 antisense oligonucleotide, in active Crohn's disease.
BACKGROUND In a phase 2 study, mongersen, an oral antisense oligonucleotide targeting Smad7, was effective in inducing clinical remission in approximately 60% of patients with active Crohn's disease (CD). AIM In a post hoc analysis to evaluate those patient disease characteristics that may have influenced the efficacy and safety of mongersen therapy. METHODS Patients with steroid-dependent/...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2018
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2017.08.035